韩国国立忠北大学临床试验证实：

岩藻多糖具有抗幽门螺杆菌活性

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Lab Anim Res, 2014: 30(3), 131-135

Anti-Helicobacter pylori activities of FEMY-R7 composed of fucoidan and evening primrose extract in mice and humans

Abstract:

Helicobacter pylori-eliminating effects of FEMY-R7, composed of fucoidan and evening primrose extract, were investigated in mice and humans. Male C57BL/6 mice were infected with the bacteria by intragastric inoculation (1×109 CFU/mouse) 3 times at 2-day intervals, and simultaneously, orally treated twice a day with 10 or 100 mg/kg FEMY-R7 for 2 weeks. In Campylobcter-like organism-detection test, FEMY-R7 markedly reduced the urease-positive reactivity. In a clinical sudy, human subjects, confirmed to be infected with Helicobacter pylori, were orally administered twice a day with a capsule containing 150 mg FEMY-R7 for 8 weeks. FEMY-R7 significantly decreased both the Delta over baseline-value in urea breath test and the serum pepsinogens I and II levels. The results indicate that FEMY-R7 not only eliminates H. pylori from gastric mucosa of animals and humans, but also improves gastric function.

First Authors:

Tae-Su Kim

Correspondence:

Yun-Bae Kim

All Authors:

Tae-Su Kim, Ehn-Kyoung Choi, Jihyun Kim, Kyungha Shin, Sung-Pyo Lee, Youngjin Choi, Joseph H. Jeon, Yun-Bae Kim

2014-09-01 Article